Tobacco and Tobacco-Related Oral Lesions: Current Concepts and Updates
DOI:
https://doi.org/10.48165/ajm.2025.8.02.14Keywords:
Tobacco, Oral potentially malignant disorders, Oral leukoplakia, Oral submucous fibrosis, Smokeless tobacco, Oral cancerAbstract
Tobacco use remains a leading preventable cause of morbidity and mortality worldwide and is strongly linked to numerous oral mucosal lesions, ranging from reversible keratotic changes to Oral squamous cell carcinoma. Both smoked and smokeless tobacco damage oral tissues through chemical, thermal, and immunologic mechanisms. Emerging products such as electronic cigarette and heat-not-burn device present new challenges for dental professionals. Tobacco-related lesions include smoker’s palate, tobacco pouch keratosis, oral leukoplakia, erythroplakia, oral submucous fibrosis, and OSCC, many classified as oral potentially malignant disorders. Early detection is essential to reduce malignant transformation and improve prognosis. Advances in molecular biology and salivary diagnostics, including biomarker and immunologic testing, have enhanced early identification. Dental professionals play a vital role in screening, patient education, tobacco cessation counseling, and timely intervention to improve overall oral and systemic health outcomes.Downloads
References
Singh, D., Shukla, D., Mehta, D. N., Shukla, C., Gulati, G. S., & Dhimole, A. (2024). Correlation between lipid profile and progression of oral cancer in the population of Madhya Pradesh. South East European Journal of Public Health, 25(S2), 2718–2722.
Mehta, D., Singh, N., Agrawal, K., Patel, M., Shah, V., & Oza, D. (2025). Evaluation of serum C-reactive protein levels in patients with oral submucous fibrosis and control group: A comparative study. Advances in Human Biology, 15, 445–448.
Nayak, D. S., Dave, A., Manek, P. V., Jambhekar, S. V., Shetty, R. R., Syed, N. K., et al. (2026). Evaluating alkaline phosphatase level and inflammation parameters in smokers with chronic periodontitis. Advances in Human Biology, 16(1), 161–167.
Panda, A., Gupta, N., Balan, U., Patadiya, H. H., Sahoo, S. K., Kumar, M., et al. (2025). In vitro study on the effect of smoking and alcohol on the proliferation of oral cancer cells. Journal of Pharmacy and Bioallied Sciences, 17, S1322–S1324.
Kashyap, P., Mehta, T., Raval, C., Manek, P. V., Kewalia, K., Guruprasad, Y., et al. (2024). Clinical correlation of types and forms of smokeless quid (tobacco and arecanut) and occurrence of oral mucosal lesions: A cross-sectional study. Journal of Pharmacy and Bioallied Sciences, 16, S218–S224.
Singh, N., Mehta, D. N., Jadeja, N. R., Chavda, H. R., Mansata, A. V., Amin, G., et al. (2025). Awareness and knowledge of oral cancer amongst dental patients in North Gujarat region: A questionnaire-based study. Journal of Pharmacy and Bioallied Sciences, 17, S2791–S2793.
Faster Capital. (2025, March 31). Tobacco tax and alternative nicotine products: An evolving landscape. Retrieved February 20, 2026, from https://fastercapital.com/content/Tobacco-tax-and-alternative-nicotine-products--An-evolving-landscape.html
Tarsariya, V. M., Raval, N., Mehta, D. N., Asrani, M. K., Asrani, V. K., & Barot, K. S. (2021). Evaluation of serum immunoglobulin (IgG, IgM, IgA) in oral cancer patients: A case-control study. Journal of Indian Academy of Oral Medicine and Radiology, 33(2), 189–194.
Majumder, P., Thomas, P. A., Motghare, V., Manek, P. V., Nazneen, L., Basak, S., et al. (2024). Effectiveness of structured teaching program on adolescent knowledge of tobacco consumption: A randomized control trial. Journal of Pharmacy and Bioallied Sciences, 16, S3464–S3466.
World Health Organization. (2021). WHO global report on trends in prevalence of tobacco use 2000–2025. Geneva: World Health Organization.
Jaswal, N., Bhatt, G., & Goel, S. (2023). Awareness of electronic cigarettes in India: Findings from the 2016–2017 Global Adult Tobacco Survey (GATS). Tobacco Prevention & Cessation, 9, 03.
Patidar, R. C., Manek, P. V., & Patel, M. S. (2025). Predictors and prevalence of smokeless tobacco use and its awareness in urban subjects having pulmonary tuberculosis. European Journal of Cardiovascular Medicine, 15(11).
Sargaiyan, V., Singh, S., Shukla, R., Tanwar, A. S., Mehta, T., Manek, P. V., Patel, B. J., & Patel, K. J. (2024). Hematological profile of OSMF patients with increasing severity. Bioinformation, 20(4), 353–357.
Khan, S., & Mehta, D. N. (2024). Role of habit behaviours in severity of oral lichen planus, oral submucous fibrosis and leukoplakia: A cross-sectional study. Journal of Advanced Zoology, 45(1), 698–700.
National Oral Cancer Registry. (2026). Oral cancer risk factors. Retrieved February 20, 2026.
Mehta, D. N. (2012). Lycopene: Structure, pharmacokinetics and role in oral cancer precancerous lesions. Journal of Research and Advancement in Dentistry, 1(2), 44–49.
Tarsariya, V. M., Mehta, D. N., Raval, N., Patadiya, H. H., Vachhrajani, K., & Ashem, A. (2020). Evaluation of serum immunoglobulin (IgG, IgM, IgA) in potentially malignant disorders of oral cavity: A case-control study. Journal of Oral Biology and Craniofacial Research, 10(4), 665–669.
Kumar, C., Priyankesh, Pandey, V., Rijhwani, A., Kumar, S., Jaideepa, et al. (2024). Assessment of potentially malignant disorders among men and women in South Bihar population. Journal of Pharmacy and Bioallied Sciences, 16, S456–S458.
Anbazhagan, S., Patadiya, H. H., Verma, A., Parmar, Y., Shukla, P., & Qureshi, A. A. (2025). Reviewing the evidence on diet and risk reduction for cancer prevention through lifestyle changes. Health Leaders Quality of Life, 4, 608.
Tokayev, K. J. (2023). Molecular mechanisms of tobacco-derived nitrosamines in oral squamous cell carcinoma (OSCC). International Journal of Applied Health Care Analytics, 8(7), 11–20.
John, H. A. S., Dakhale, R., Sedani, S., & Ahuja, K. P. (2023). Smoker’s palate: An often misunderstood benign lesion of the oral cavity. Cureus, 15(11), e48868.
Arakeri, G., & Brennan, P. A. (2013). Oral submucous fibrosis: An overview of the aetiology, pathogenesis, classification and principles of management. British Journal of Oral and Maxillofacial Surgery, 51(7), 587–593.
Senaratne, N. L. M., Yung On, C., Shetty, N. Y., & Gopinath, D. (2024). Effect of different forms of tobacco on the oral microbiome in healthy adults: A systematic review. Frontiers in Oral Health, 5, 1310334.
Donald, P. M., Renjith, G., & Arora, A. (2017). Tobacco pouch keratosis in a young individual: A brief description. Journal of Indian Society of Periodontology, 21(3), 249–251.
Warnakulasuriya, S., Kujan, O., Aguirre-Urizar, J. M., Bagan, J. V., González-Moles, M. Á., Kerr, A. R., et al. (2021). Oral potentially malignant disorders: A consensus report from an international seminar on nomenclature and classification convened by the WHO Collaborating Centre for Oral Cancer. Oral Diseases, 27(8), 1862–1880.
Neville, B. W., & Day, T. A. (2002). Oral cancer and precancerous lesions. CA: A Cancer Journal for Clinicians, 52(4), 195–215.
E-cigarettes, heat-not-burn and smokeless tobacco products. (2020). Breathe (Sheffield), 16(1), 161.
Kadaksha, P., Zohra, B., Patadiya, H. H., Kumar, S. A., Suri, S., Parthasarathy, S., & Gupta, S. (2024). Systematic review of educational efforts on early cancer detection awareness among college students. Seminars in Medical Writing and Education, 3, 531.
Kumar, D., Patadiya, H. H., Sawhney, A., Chavda, H. R., Nazneen, L., Sahoo, N., et al. (2025). Evaluation of salivary biomarkers in the early detection of oral squamous cell carcinoma. Journal of Pharmacy and Bioallied Sciences, 17, S1319–S1321.
Manek, P. V., Mehta, D. N., & Laddha, R. (2022). Nanodentistry: A revolutionary approach in dental sciences. Academic Journal of Medicine, 5(2), 5–10.
Gupta, A., Singh, M., Ibrahim, R., & Mehrotra, R. (2007). Utility of toluidine blue staining and brush biopsy in precancerous and cancerous oral lesions. Acta Cytologica, 51(5), 788–794.
Ram, S., & Siar, C. H. (2005). Chemiluminescence as a diagnostic aid in the detection of oral cancer and potentially malignant epithelial lesions. International Journal of Oral and Maxillofacial Surgery, 34(5), 521–527.
Tiwari, A., Ghosh, A., Agrawal, P. K., Reddy, A., Singla, D., Mehta, D. N., et al. (2023). Artificial intelligence in oral health surveillance among underserved communities. Bioinformation, 19(13), 1329–1335.
Katria, V., Dhaka, P., Parihar, J., Chaudhari, M. A., Soni, J., & Bhardwaj, M. D. (2025). Oral cancer, oral health and potentially malignant disorders: A review. Journal of Advanced Medical and Dental Sciences Research, 13(2), 25–30.
