Efficacy and Safety of Dapagliflozin as Adjunct Therapy in Patients with Type 2 Diabetes Mellitus Inadequately Controlled on Metformin and Sulfonylurea

Sudeep Jain; Reena Verma; Sudeep Pathak; Chhaya Bohare

doi:10.48165/ajm.2026.9.02.34

Abstract

Background: Achieving adequate glycaemic control remains challenging in patients with type 2 diabetes mellitus (T2DM) receiving metformin and sulfonylurea. Dapagliflozin offers an additional glucose-lowering mechanism through inhibition of renal sodium-glucose cotransporter-2.

Aim: To evaluate the efficacy and safety of dapagliflozin as adjunct therapy in patients with T2DM inadequately controlled on metformin and sulfonylurea.

Materials and Methods: This prospective observational study included 147 patients with inadequately controlled T2DM receiving metformin and sulfonylurea. Dapagliflozin 10 mg once daily was added to the existing treatment regimen. Changes in HbA1c, fasting and postprandial blood glucose, body weight, BMI, blood pressure and laboratory safety parameters were assessed during follow-up. Adverse drug reactions were also recorded. Statistical significance was set at p

KeywordsDapagliflozintype 2 diabetes mellitusmetforminsulfonylureaglycaemic controlHbA1cadverse drug reactions

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