Assessment of Correlation of Vitamin D Level with Coronary Artery Disease
Keywords:
Coronary Artery Disease, Dyslipidemia, Vitamin DAbstract
Background: Cardiovascular disease (CVD) is the leading cause of death in the developed world. The present study was conducted to assess correlation of plasma 25-Hydroxy-Vitamin D level with angiographic severity in coronary artery disease. Subjects and Methods: The present study was conducted on 120 patients of CAD. Group I were cases and group II were control. Hypertension, type II diabetes mellitus status, smoking etc. was recorded. 2 ml of blood sample was taken from all patients and measurement of 25(OH) vit D levels was performed. Results: The mean BMI in group I was 24.6 kg/m2and 24.8 kg/m2in group II, smoking habit was seen in 78 in group I and 34 in group II, hypertension was seen in 65 in group I and 26 in group II, diabetes was seen in 52 in group I and 30 in group II, alcoholism in 36 in group I and 10 in group II, dyslipidemia was seen in 48 in group I and 15 in group II. The mean 25 (OH) vitamin D in group I was 15.1 ng/ml and 19.6 ng/ml in group II. The difference was significant (P< 0.05). Maximum dyslipidemia (80.5%) patients had low vitamin D level followed by DM, smoking, BMI, alcoholism and alcoholism. There was no correlation between risk factors and vitamin D deficiency (P> 0.05). Conclusion: Authors found that in cases, vitamin D level was lowered as compared to control, however, there was no correlation between risk factors and CAD.
Downloads
References
1. Targher G, Bertolini L, Padovani R, Zenari L, Scala L, Cigolini M, et al. Serum 25-hydroxyvitamin D3 concentrations and carotid artery intima-media thickness among type 2 diabetic patients. Clin Endocrinol. 2006;65(5):593–597. Available from: https://dx.doi.org/10.1111/j.1365-2265.2006.02633.x.
2. Sugden JA, Davies JI, Witham MD. Vitamin D improves endothelial function in patients with type 2 diabetes mellitus and low vitamin D levels. Diabet Med. 2008;25:320–325.
3. van Etten E, Mathieu C. Immunoregulation by 1,25- dihydroxyvitamin D3: Basic concepts. J Steroid Biochem Mol Biol. 2005;97(1-2):93–101. Available from: https://dx.doi.org/ 10.1016/j.jsbmb.2005.06.002.
4. Lai H, Fishman EK, Gerstenblith G, Brinker JA, Tong W, Bha tia S, et al. Vitamin D deficiency is associated with significant coronary stenoses in asymptomatic African American chronic cocaine users. Int J Cardiol. 2012;158(2):211–216. Available from: https://dx.doi.org/10.1016/j.ijcard.2011.01.032.
5. Tarcin O, Yavuz DG, Ozben B, Telli A, Ogunc AV, Yuksel M, et al. Effect of Vitamin D Deficiency and Replacement on Endothelial Function in Asymptomatic Subjects. J Clin Endocrinol Metab. 2009;94(10):4023–4030. Available from: https://dx.doi.org/10.1210/jc.2008-1212.
6. Pilz S, Dobnig H, Fischer JE, Wellnitz B, Seelhorst U, Boehm BO, et al. Low Vitamin D Levels Predict Stroke in Patients Referred to Coronary Angiography. Stroke. 2008;39(9):2611– 2613. Available from: https://dx.doi.org/10.1161/strokeaha. 107.513655.
7. Reis JP, von Mühlen D, Michos ED, Miller ER, Appel LJ, Araneta MR, et al. Serum vitamin D, parathyroid hormone levels, and carotid atherosclerosis. Atherosclerosis. 2009;207(2):585–590. Available from: https://dx.doi.org/10. 1016/j.atherosclerosis.2009.05.030.
8. Chitalia N, Recio-Mayoral A, Kaski JC, Banerjee D. Vita min D deficiency and endothelial dysfunction in non dialysis chronic kidney disease patients. Atherosclerosis. 2012;220(1):265–268. Available from: https://dx.doi.org/10. 1016/j.atherosclerosis.2011.10.023.
9. Khazai N, Judd SE, Tangpricha V. Calcium and vitamin D: Skeletal and extraskeletal health. Curr Rheumatol Rep. 2008;10(2):110–117. Available from: https://dx.doi.org/10. 1007/s11926-008-0020-y.
10. Tarçın O, Yavuz DG, Özben B, Telli A, Öğünç AV, Yüksel M. Effect of vitamin D deficiency and replacement on endothelial
function in asymptomatic subjects. J Clin Endocrinol Metab. 2009;94:4023–4053.
11. Akin F, Ayça B, Köse N, Duran M, Sarı M, Uysal OK, et al. Serum Vitamin D Levels Are Independently Associated With Severity of Coronary Artery Disease. J Invest Med. 2012;60(6):869–873. Available from: https://dx.doi.org/10. 2310/jim.0b013e31825457cb.
12. Baktır AO, Dogan Y, Sarlı B, Sahin O, Demirci E, Akpek M, et al. Relationship between serum 25-hydroxyvitamin D levels and the SYNTAX score in patients with acute coronary syndrome. Anatolian J Cardiol. 2017;17(4):293–293.