Thyroid Dysfunction in Patients with Liver Disease
Keywords:
Liver cirrhosis, Hypothyroidism, Ethanol related liver disease, Hepatitis B related liver disease,, CTP scoreAbstract
Background: Liver disease related to alcohol (Ethanol, ethylalcohol) is very common global problem and is one of the major medical complications of alcohol abuse. Daily consumption is usual for causation of liver disease. Aim: To estimate the prevalence of thyroid dysfunction in patients with liver disease. Subjects and Methods: Early morning fasting serum thyroid stimulating hormone (TSH), serum total free thyroxine (FT4) and free triiodothyronine (FT3) was measured by radioimmunoassays in 100 index patients with liver cirrhosis who did not have history of thyroid diseases. Study Period: November 2018 to October 2019 The age of study population was in the range of 25- 65 years. Out of 100 patients, 75 were males and 25 were females. Conclusion: Abnormalities in circulating thyroid hormone concentrations i.e hypothyroidism is noted especially in those with ethanol related liver cirrhosis and it is associated with more advanced liver disease.
Downloads
References
1. P. Burra, J.A. Franklyn, D.B.Ramsden, E.Elias and M.C.Sheppard .Severity of alcoholic liver disease and markers of thyroid and steroid status Post graduate medical journal 1992 october;68(804-810).
2. Y Israel, PG Walfish, H Orrego, J Blake, H Kalant. Thyroid hormone levels in alcoholic liver diseases. Gastroenterology Vol.76, issue 1, January 1979; 116-122
3. Hepner GW, Chopra IJ .Serum thyroid hormone levels in patients with liver disease. Archive Internal Medicine .1979 Oct; 139(10); 1117-20.
4. S Nomura, C S Pittman, J B Chambers, Jr, M W Buck and T Shimizu. .Reduced peripheral conversion of thyroxine to triiodothyronine in patients with hepatic cirrhosis. The Journal of Clinical investigation 1975 September; 56(3) 643-652.
5. JanniA, etal. The prognostic value of thyroid function tests in liver cirrhosis. In Langer M Chiandussi L,Chopra I J and Martin L,eds, The Endocrines and The Liver, London, Academic Press, 1982; 232-6
6. L`age M, Meinhold H, Wenzel KW ,Schlesinger H. Relations between serum levels of TSH,TBG,T4,T3,rT3 and various histological classified chronic liver diseases. Journal of Endocrinology investigations 1980 oct-dec; 3(4);379-83.
7. George C. Schussler, M.D.,Fenton Schaffner, M.D., and Felice korn M.S.Increased serum thyroid hormone binding and decreased free hormone in chronic liver disease. The New England Journal of Medicine 1978; 299:510- 515.
8. Williams Text book of Endocrinology Edition 11.Henry M. Krokenberg, Shlomo Melmed Kenneth S.Polonsky, and P.Reed Larsen.
9. M Borzio, R Caldara, F Borzio, V Piepoli et al. Thyroid function tests in chronic liver disease: evidence for multiple abnormalities despite clinical euthyroidism. GUT, an International Journal of Gastroenterology and Hepatology; 1983 July; 24(7); 631-636.
10. Oxford Text book of Clinical hepatology; Vol_2.
