Assessment of Inflammatory Markers IL- 6 and TNF- Alpha in Newly Diagnosed Type II Diabetics without Hypertension in Comparison with Non-Diabetic Normotensive Subjects
Keywords:
Diabetic, Normotensive, TNF- alphaAbstract
Background: The present study was conducted to assess inflammatory markers IL- 6 and TNF- alpha in newly diagnosed type II diabetics without hypertension. Subjects and Methods: 68 types of II diabetes mellitus patients and equal numbers of normotensive non-diabetic subjects were also recruited. Glycated hemoglobin (HbA1c) levels, TNF- alpha and IL- 6 were determined. Results: The mean IL- 6 level in group I was 17.4 pg/ml and in group II was 4.2 pg/ml. TNF- alpha level in group I was 35.8 pg/ml and in group II was 12.5 pg/ml. The difference was significant (P< 0.05). Conclusion: TNF- alpha and IL- 6 level was higher among diabetic patients as compared to healthy normotensive non-diabetic subjects.
Downloads
References
1. Donath MY, Shoelson SE. Type 2 diabetes as an inflammatory disease. Nat Rev Immunol. 2011;11(2):98–107. Available from: https://dx.doi.org/10.1038/nri2925.
2. Krakoff J, Funahashi T, Stehouwer CDA, Schalkwijk CG, Tanaka S, Matsuzawa Y, et al. Inflammatory Markers, Adiponectin, and Risk of Type 2 Diabetes in the Pima Indian. Diabetes Care. 2003;26(6):1745–1751. Available from: https: //dx.doi.org/10.2337/diacare.26.6.1745.
3. Pradhan AD, Manson JE, Rifai N, Buring JE, Ridker PM. C reactive protein, interleukin 6, and risk of developing type 2 diabetes mellitus. JAMA. 2001;286(3):327–334. Available from: https://doi.org/10.1001/jama.286.3.327.
4. Salomaa V, Havulinna A, Saarela O, Zeller T, Jousilahti P, Jula A, et al. Thirty-One Novel Biomarkers as Predictors for Clinically Incident Diabetes. PLoS One. 2010;5(4):e10100– e10100. Available from: https://dx.doi.org/10.1371/journal. pone.0010100.
5. Nadeem A, Naveed AK, Hussain MM, Raza SI. Correlation of inflammatory markers with type 2 Diabetes Mellitus in Pakistani patients. J Postgrad Med Inst. 2013;27(03):267–273.
6. Bertoni AG, Burke GL, Owusu JA, Carnethon MR, Vaidya D, Barr RG, et al. Inflammation and the Incidence of Type 2 Diabetes: The Multi-Ethnic Study of Atherosclerosis (MESA). Diabetes Care. 2010;33(4):804–810. Available from: https: //dx.doi.org/10.2337/dc09-1679.
7. Singhai M, Faizy A, Goyal R, Siddiqui S. Evaluation of TNF α and IL-6 levels in obese and non-obese diabetics: Pre- and
postinsulin effects. N Am J Med Sci. 2012;4(4):180–180. Available from: https://dx.doi.org/10.4103/1947-2714.94944. 8. Al-Shukaili A, AL-Ghafri S, Al-Marhoobi S, Al-Abri S, Al Lawati J, Al-Maskari M. Analysis of Inflammatory Mediators in Type 2 Diabetes Patients. Int J Endocrinol. 2013;2013:1–7. Available from: https://dx.doi.org/10.1155/2013/976810. 9. Agyemang C, Beune E, Meeks K, Owusu-Dabo E, Agyei Baffour P, de Graft Aikins A, et al. Rationale and cross sectional study design of the Research on Obesity and type 2 Diabetes among African Migrants: the RODAM study. BMJ Open. 2015;4(3):e004877–e004877. Available from: https: //dx.doi.org/10.1136/bmjopen-2014-004877.
10. Darko SN, Yar DD, Owusu-Dabo E, Awuah AAA, Dapaah W, Addofoh N. Variations in levels of IL-6 and TNF-α in type 2 diabetes mellitus between rural and urban Ashanti Region of Ghana; 2015. Available from: https://dx.doi.org/10.1186/ s12902-015-0047-9.
11. Lainampetch J, Panprathip P, Phosat C, Chumpathat N, Prangthip P, Soonthornworasiri N, et al. Association of Tumor Necrosis Factor Alpha, Interleukin 6, and C-Reactive Protein with the Risk of Developing Type 2 Diabetes: A Retrospective Cohort Study of Rural Thais. J Diabetes Res. 2019;2019:1–9. Available from: https://dx.doi.org/10.1155/2019/9051929.
12. Bashir H, Bhat SA, Majid S, Hamid R, Koul RK, Rehman MU, et al. Role of inflammatory mediators (TNF-α, IL-6, CRP), biochemical and hematological parameters in type 2 diabetes mellitus patients of Kashmir. Med J Islam Repub Iran. 2020;34:5–5. Available from: https://doi.org/10.34171/mjiri. 34.5.
