Examination of Pervasiveness of Elevated Serum Uric Acid Level and Microalbuminuria in Prehypertension

Authors

  • Sunjay Pathak Assistant Professor, Department of General Medicine, Varun Arjun Medical College and Rohilkhand Hospital, Banthra, Shahjehanpur, Uttar Pradesh, India Author
  • Mahipal Singh Puri Department of Medicine, Rajshree Medical Research Institute, Bareilly, Uttar Pradesh, India. Author

Keywords:

Serum Uric Acid, Microalbuminuria, Prehypertension

Abstract

 

Background: The relationship between uric acid and microalbuminuria in healthy adults without other cardiovascular risk factors may help to clarify the role of uric acid in cardiovascular disease. In this study, we examined that elevated serum uric acid level was associated with microalbuminuria. Subjects and Methods: Study was done on both male and female prehypertensive patients of age more than 18 years and less than 60, admitted in wards and attending OPD. Controls were normotensive patients admitted in wards who were matched for age, sex and confounding factors. Results: Hyperuricemia was found in 53 (15.14%) patients with prehypertension compared to 32 (9.14%) patients with normal BP. Thus hyperuricemia was seen in patients of prehypertension which was highly significant as P<0.001. Conclusion: In conclusion we found that microalbuminuria and hyperuricemia are significantly more prevalent among prehypertensive subjects as compared to normotensive subjects. 

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References

1. Chizyński K, Rózycka M, Hyperuricemia. Blood Pressure Measurement Guidelines for Physical Therapists. Cardiopulm Phys Ther J. 2011;22(2):5–12.

2. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67(5):1739–1742. Available from: https://dx. doi.org/10.1111/j.1523-1755.2005.00273.x.

3. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, et al. Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism. Hypertension. 2001;38(5):1101–1106. Available from: https: //dx.doi.org/10.1161/hy1101.092839.

4. Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, et al. Hyperuricemia Causes Glomerular Hypertrophy in the Rat. Am J Nephrol. 2003;23(1):2–7. Available from: https://dx.doi.org/10.1159/000066303.

5. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q. Hyperuricemia induces a primary renal arteriopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol. 2002;282(6):991–997.

6. Sánchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaría J, et al. Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol-Renal. 2002;283(5):F1105–F1110. Available from: https://dx.doi.org/ 10.1152/ajprenal.00170.2002.

7. Dinneen SF, Gerstein HC. The association of microalbuminuria and mortality in non-insulin-dependent diabetes mellitus. A systematic overview of the literature. Arch Intern Med. 1997;157:1413–1418.

8. Messent JWC, Elliott TG, Hill RD, Jarrett RJ, Keen H, Viberti G. Prognostic significance of microalbuminuria in insulin dependent diabetes mellitus: A twenty-three year follow-up study. Kidney Int. 1992;41(4):836–839. Available from: https: //dx.doi.org/10.1038/ki.1992.128.

9. Verdecchia P, Reboldi GP. Hypertension and microal buminuria: the new detrimental duo. Blood Pressure. 2004;13(4):198–211. Available from: https://dx.doi.org/10. 1080/08037050410016456.

10. Bianchi S, Bigazzi R, Campese VM. Microalbumin uria in essential hypertension: Significance, pathophysiol ogy, and therapeutic implications. Am J Kidney Dis. 1999;34(6):973–995. Available from: https://dx.doi.org/10. 1016/s0272-6386(99)70002-8.

11. Bigazzi R, Bianchi S, Baldari D, Campese VM. Microal buminuria predicts cardiovascular events and renal insuffi ciency in patients with essential hypertension. J Hypertens.

1998;16(9):1325–1333. Available from: https://dx.doi.org/10. 1097/00004872-199816090-00014.

12. Hillege HL, Janssen WMT, Bak AAA, Diercks GFH, Grobbee DE, Crijns HJGM, et al. Microalbuminuria is common, also in a nondiabetic, nonhypertensive population, and an independent indicator of cardiovascular risk factors and cardiovascular morbidity. J Internal Med. 2001;249(6):519–526. Available from: https://dx.doi.org/10.1046/j.1365-2796.2001.00833.x.

13. Hillege HL, Fidler V, Diercks GFH, van Gilst WH, de Zeeuw D, van Veldhuisen DJ, et al. Urinary Albumin Excretion Predicts Cardiovascular and Noncardiovascular Mortality in General Population. Circulation. 2002;106(14):1777–1782. Available from: https://dx.doi.org/10.1161/01.cir.0000031732.78052.81.

14. Klausen K, Borch-Johnsen K, Feldt-Rasmussen B, Jensen G, Clausen P, Scharling H, et al. Very Low Levels of Microalbuminuria Are Associated With Increased Risk of Coronary Heart Disease and Death Independently of Renal Function, Hypertension, and Diabetes. Circulation. 2004;110(1):32–35. Available from: https://dx.doi.org/10. 1161/01.cir.0000133312.96477.48.

15. Albuminuria D. Not only a cardiovascular/renal risk marker, but also a target for treatment? Kidney Int. 2004;66:2–6. 16. Yuyun MF, Adler AI, Wareham NJ. What is the evidence

that microalbuminuria is a predictor of cardiovascular disease events? Curr Opin Nephrol Hypertens. 2005;14(3):271– 276. Available from: https://dx.doi.org/10.1097/01.mnh. 0000165895.90748.3b.

17. Rodillasala E, Lahiguera FP, Muñoz J, Enguita CG, Amparomi ralles U, Moral D. Association between serum uric acid, metabolic syndrome and microalbuminuria in previously untreated essential hypertensive patients. Medicina clínica. 2009;132(1):1–6.

18. Knight EL, Kramer HM, Curhan GC. High-normal blood pres sure and microalbuminuria. Am J Kidney Dis. 2003;41(3):588– 595. Available from: https://dx.doi.org/10.1053/ajkd.2003. 50120.

19. Vasan RS, Larson MG, Leip EP, Evans JC, O’Donnell CJ, Kannel WB, et al. Impact of High-Normal Blood Pressure on the Risk of Cardiovascular Disease. N Eng J Med. 2001;345(18):1291–1297. Available from: https://dx.doi.org/ 10.1056/nejmoa003417.

20. Svetkey LP. Management of Prehypertension. Hypertens. 2005;45(6):1056–1061. Available from: https://dx.doi.org/10. 1161/01.hyp.0000167152.98618.4b.

21. Khosla UM, Zharikov S, Finch JL, Nakagawa T, Roncal C, Mu W, et al. Hyperuricemia induces endothelial dysfunction. Kidney Int. 2005;67(5):1739–1742. Available from: https://dx. doi.org/10.1111/j.1523-1755.2005.00273.x.

22. Viazzi F, Parodi D, Leoncini G, Parodi A, Falqui V, Ratto E, et al. Serum Uric Acid and Target Organ Damage in Primary Hypertension. Hypertension. 2005;45(5):991– 996. Available from: https://dx.doi.org/10.1161/01.hyp. 0000161184.10873.ea.

23. Mattei P, Arzilli F, Giovannetti R, Penno G, Arrighi P, Taddei S, et al. Microalbuminuria and renal haemodynamics in essential hypertension. Eur J Clin Invest. 1997;27(9):755–760. Available from: https://dx.doi.org/10.1046/j.1365-2362.1997. 1840733.x.

24. Johnson RJ, Kang DH, Feig D, Kivlighn S, Kanellis J, Watanabe S, et al. Is There a Pathogenetic Role for Uric Acid in Hypertension and Cardiovascular and Renal Disease? Hypertension. 2003;41(6):1183–1190. Available from: https: //dx.doi.org/10.1161/01.hyp.0000069700.62727.c5.

25. Johnson RJ, Segal MS, Srinivas T, Ejaz A, Mu W, Roncal C, et al. Essential Hypertension, Progressive Renal Disease, and Uric Acid: A Pathogenetic Link?: Table 1. J Am Soc Nephrol. 2005;16(7):1909–1919. Available from: https://dx.doi.org/10. 1681/asn.2005010063.

26. Mazzali M, Hughes J, Kim YG, Jefferson JA, Kang DH, Gordon KL, et al. Elevated Uric Acid Increases Blood Pressure in the Rat by a Novel Crystal-Independent Mechanism. Hypertension. 2001;38(5):1101–1106. Available from: https: //dx.doi.org/10.1161/hy1101.092839.

27. Nakagawa T, Mazzali M, Kang DH, Kanellis J, Watanabe S, Sanchez-Lozada LG, et al. Hyperuricemia Causes Glomerular Hypertrophy in the Rat. Am J Nephrol. 2003;23(1):2–7. Available from: https://dx.doi.org/10.1159/000066303.

28. Mazzali M, Kanellis J, Han L, Feng L, Xia YY, Chen Q. Hyper uricemia induces a primary renal arteriolopathy in rats by a blood pressure-independent mechanism. Am J Physiol Renal Physiol. 2002;282:991–997.

29. Sánchez-Lozada LG, Tapia E, Avila-Casado C, Soto V, Franco M, Santamaría J, et al. Mild hyperuricemia induces glomerular hypertension in normal rats. Am J Physiol-Renal. 2002;283(5):F1105–F1110. Available from: https://dx.doi.org/ 10.1152/ajprenal.00170.2002.

30. Kang DH, Han L, Ouyang X, Kahn AM, Kanellis J, Li P. Uric acid causes vascular smooth muscle cell proliferation by entering cells via a functional urate trans- porter. Am J Nephrol. 2005;25:425–433.

Published

2020-05-27

How to Cite

Examination of Pervasiveness of Elevated Serum Uric Acid Level and Microalbuminuria in Prehypertension. (2020). Academia Journal of Medicine, 3(1), 27-31. https://medjournal.co.in/index.php/ajm/article/view/132