Study of Serum Ferritin and Glycated Hemoglobin in Type 2 Diabetes Mellitus
Keywords:
Type 2 diabetes mellitus, Serum ferritin,, Glycated hemoglobinAbstract
Background: Type 2 diabetes mellitus is a common metabolic disorder of multiple etiologies. Increased levels of serum ferritin have been indicated to be associated with the etiology of the diabetic process, as well as in pathogenesis of various diabetic complications. The study aims to understand the relationship between the serum ferritin and glycated hemoglobin in type 2 diabetes mellitus. Subjects and Methods: The study was conducted at Medical College Hospital and Research Centre. A total of hundred cases of type 2 diabetes mellitus of the age group 30 – 70 years were taken for the study after satisfying the inclusion and exclusion criteria. Hundred healthy volunteers in the age group 30 – 70 years, sex matched during the same period was included in the study under the control group. Results: Serum ferritin level was significantly high in cases compared to controls. There was moderate correlation between serum ferritin and glycated hemoglobin. There was significant increase in serum ferritin levels in type 2 diabetics compared to the controls. There was a moderate correlation between serum ferritin and glycated hemoglobin. Conclusion: This study explores the possibility of finding serum ferritin as a marker to explain the oxidative stress process in type 2 diabetes mellitus. This valuable information would be helpful in proper medical intervention.
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References
1. Mann N, W D, Dudman N, ―The effect of diet on plasma hommolysteine concentration in healthy male subjects‖. EurJuin NUTV, 2000. 71:682-692.
2. Roselti L, Rothman D L, ―The effect of dietary protein on in vivo insulin action and liver glycogen repletion‖. Am J Physiol, 1989,257: E212-E219.
3. Mac Donald MJ, Cook JD, ―Large amount ferritin in the pancreatic insulin cell and its stimulation by glucose‖ FASEB J 1994,8 : 777- 781.
4. Rahier J R, Loozen S, Goebbels RM, ―The homochromatic human pancreas immunohistochemical and ultra structural study‖. Diabetelogia 1987, 30 : 5-12.
5. Bertelson M, Anggard EE, Carrier MJ, ―Oxidative stress impairs insulin internalization in endothelial cells vivo‖. Diabchologia 2001, 44:605-613.
6. Reif DW, ―Ferrritin as a source of iron for oxidative damage‖. Free Rad Biol Med 1992, 12 :417-427.
7. Jose Manuel Fernandez-Real, Abel Lopez-Berme-jo, and Ricart. 2002. Perspectives in diabetes: cross talk between iron metabolism and diabetes‖. Diabetes –vol15 :2348-2354.
8. Fernandez-Real JM Ricat W, Amoyo E, ―Serum ferritin as a component of the insulin resistance syndrome‖ Diabetes care 1998, 21:62-68.
9. Wannamethee SG. Perny IJ, Shaper AG, ―Hematocrit and risk of NIPPM.Diabetes 1996, 45: 576-579.
10. Earls, Ford, Mary E, Logs Well, ―Diabetes and serum ferritin concentration among US Adults‖. Diabetes care, 1999; 22(12): 1978- 1983.
11. Kim Hee Nan., et Al., 2000. ―Serum ferritin in healthy subjects and type 2 diabetic patients‖. Yonsei Medical Journal. 41(3):387-392. 12. Van ost BA, VandenBeld B, ―Measurement of ferritin in serum
13. SundararamanSwaminathan, Visian A, Sudhir V, ―The role of iron in diabetes and its complications‖. Diabetes care, 2007; 28: 1-20. 14. Dymock MWJC, Payke DA, Oakley WG, Roger William,
―Observations as the pathogenesis complications and treatment of diabetes, 115 cases of hemochromatosis‖. American J Medicine, 1972; 203-209.
15. Jehn ML, Guallar E, Clark JM, ―A prospective study of plasma ferritin level and incident diabetes : the atheroscelosis risk in communities.[ARIC] study‖, Am J epidemiol 2007 ; 165 : 1047-1054
16. Jeeven K. Shetty, MungliPrakash, Mohammed S Ibahim, ―Relationship between free iron and glycated hemoglobin in uncontrolled type 2 diabetes patients associated with complications‖. Indian Journal of clinical. Biochemistry, 2008; 23(1) 67-70.
