To Evaluate Serum Uric Acid as a Risk Factor For Micro- Vascular Complications of Diabetes Mellitus

Authors

  • Nagendra Singh Chauhan Associate Professor, Department of Medicine, FH Medical College, Tundla. Author

Keywords:

Diabetes Mellitus, Uric Acid, Vascular Complications

Abstract

Background: Diabetes Mellitus (DM) as a metabolic disorder of multiple etiology, characterized by chronic hyperglycaemia with disturbances  of carbohydrate, protein and fat metabolism. The present study was conducted to evaluate serum uric acid as a risk factor for micro- vascular  complications of diabetes mellitus. Subjects and Methods: The present study was conducted on 84 patients with type II diabetes mellitus of  both genders. 10 ml of blood was obtained for assessment of blood glucose and uric acid level. Results: Age group 40-60 years had 46, 60-80  years had 25 and >80 years had 13 patients. Hyperuricemia was positive in 56 and negative in 28. The difference was significant (P< 0.05).  Out of 56 patients with hypertension, 42 had high and 14 had low serum uric acid level. Out of 28 patients who had not hypertension, 18 had  high serum uric acid and 10 had low. The difference was significant (P< 0.05). Among 48 patients who had stroke, 28 had high serum uric acid  and 20 had low uric acid. The difference was significant (P< 0.05). Conclusion: Elevated serum uric acid levels in type 2 diabetes mellitus  cause more micro vascular and macro vascular complications. 

Downloads

Download data is not yet available.

References

1. Heinig M, Johnson RJ. Role of uric acid in hypertension, renal disease and metabolic syndrome. Cleve Clin J Med 2006;73(12):1059-1064. 2. American Diabetes Association. Diagnosis and classification of diabetes mellitus. Diabetes Care 2014;37: 81- 90.

3. Gagliardi AC, Miname MH, Santos RD. Uric acid: A marker of increased cardiovascular risk. Atherosclerosis 2009; 202(1):11-17. 4. Cook DG, Shaper AG, Thelle DS, et al. Serum uric acid, serum glucose and diabetes: relationships in a population Study. Postgrad Med J 1986;62(733):1001-1006.

5. Bonakdaran S, Hami M, Shakeri MT. Hyperuricemia and albuminuria in patients with type 2 diabetes mellitus. Iran J Kidney Dis 2011;5(1):21- 24.

6. Bandaru P, Shankar A. Association between serum uric acid levels and diabetes mellitus International Journal of Endocrinology 2011;2011:1-6. 7. Kodama S, Sugawara A, Saito K, et al. Association between serum uric acid and development of type 2 diabetes. Diabetes Care 2009;32(9):1737-1742.

8. Cirillo P, Sato W, Reungjui S, et al. Uric acid the metabolic syndrome and renal disease. J Am SocNephrol 2006;17(12 Suppl 3): 165-168. 9. Zoppini G, Targher G, Chonchol M, et al. Serum uric acid levels and incident chronic kidney disease in patients with type 2 diabetes and preserved kidney function. Diabetes Care 2012;35(1):99-104. 10. El-WakfAM, Abbas TM, El-Baz RA, et al. Role of hypertension and metabolic abnormalities in the development of diabetic nephropathy among Egyptian patients with type 2 diabetes. Nature and Science, 2011; 9(7):220-226.

Published

2019-08-30

How to Cite

To Evaluate Serum Uric Acid as a Risk Factor For Micro- Vascular Complications of Diabetes Mellitus . (2019). Academia Journal of Medicine, 2(1), 12-14. https://medjournal.co.in/index.php/ajm/article/view/204