Analysis of Cardiac Profile in Patients with Liver Cirrhosis: An Observational Study
Keywords:
Cardiac, Cirrhosis, LiverAbstract
Background: Cirrhosis is defined as the histological development of regenerative nodules surrounded by fibrous bands in response to chronic liver injury that leads to portal hypertension and end stage liver disease.Studies suggested that underlying cardiac dysfunction precedes the development of Hepato-renal syndrome. hence; under the light of above mentioned data, we planned the present study to assess the cardiac profile in patients with liver cirrhosis. Subjects and Methods: A total of 30 liver cirrhosis patients were included in the present study. Routine haematological profile of all the patients was carried was assessed. Transthoracic 2 D echo with Doppler was done in all patients and parameters (Left atrial enlargement, Left ventricular diastolic dysfunction) were assessed. Liver disease was staged according to Child-Pugh’s score. All the results were compiled and analyzed by SPSS software. Results: Significant results were obtained while correlating the patients with left atrial enlargement and severity of liver cirrhosis. Also, significant results were obtained while correlating the patients with diastolic dysfunction and severity of liver cirrhosis. Conclusion: Cardiac parameters are directly correlated with the severity of the disease in liver cirrhosis patients.
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References
1. Bircher J, Benhamou JP, McIntyre N, Rizzetto M, Rodes J, editors. Oxford Textbook of Clinical Hepatology. 2nd Edition Oxford University Press; 1999.
2. Schiff ER, Sorrell MF, Maddrey EC, editors. Schiff’s Diseases of the Liver. 9th Edition Lippincott, Williams & Wilkins; Philadelphia: 2003. 3. Desmet VJ, Roskams T. Cirrhosis reversal: a duel between dogma and myth. J Hepatol. 2004;40:860–7.
4. Digestive diseases in the United States: Epidemiology and Impact. NIDDK; Bethesda, MD: 1994. NIH Publication No. 94-1447. 5. Poynard T, Bedossa P, Opolon P. Natural history of liver fibrosis progression in patients with chronic hepatitis C. The OBSVIRC, METAVIR, CLINIVIR, and DOSVIRC groups. Lancet. 1997;349:825–32.
6. Matsumori A. Hepatitis C virus infection and cardiomyopathies. Circ Res. 2005;96:144–147.
7. Omura T, Yoshiyama M, Hayashi T, Nishiguchi S, Kaito M, Horiike S, Fukuda K, Inamoto S, Kitaura Y, Nakamura Y, et al. Core protein of hepatitis C virus induces cardiomyopathy. Circ Res. 2005;96:148– 150.
8. Bellentani S, Pozzato G, Saccoccio G, et al. Clinical course and risk factors of hepatitis C virus related liver disease in the general population: report from the Dionysos study. Gut. 1999;44:874–80.
9. Cattau E, Benjamin SB, Knuff TE, Castell DO. The accuracy of the physical exam in the diagnosis of suspected ascites. JAMA. 1982;247:1164–66.
10. Kavoliuniene A, Vaitiekiene A, Cesnaite G. Congestive hepatopathy and hypoxic hepatitis in heart failure: a cardiologist’s point of view. Int J Cardiol. 2013;166:554–558.
11. Terrier B, Karras A, Cluzel P, Collet JP, Sène D, Saadoun D, Cacoub P. Presentation and prognosis of cardiac involvement in hepatitis C virus-related vasculitis. Am J Cardiol. 2013;111:265–272.
12. Yap EML, Supe MGS, Yu II. Cardiac Profile of Filipino Patients With Liver Cirrhosis: A 10-Year Study.Cardiol Res. 2018;9(6):358-363