Maternal Chronic Periodontitis as a Risk Factor for Preterm Birth and Low Birth Weight: A Hospital-Based Case Control Study

Authors

  • Manisha Pathak Author
  • Madhvika Patidar Author
  • John Kujur Author
  • Himanshu Sharma Author
  • Shilpi Tyagi Author
  • Akanksha Singh Author

Keywords:

Periodontitis, Preterm birth, Low birth weight, Pregnancy, Case-control study, CPITN

Abstract

Background: Preterm birth (PTB) and low birth weight (LBW) are main causes of neonatal morbidity and mortality worldwide. Evidence suggests a potential link between maternal chronic periodontitis and adverse pregnancy outcomes. Objectives: This hospital-based case-control study aimed to assess the association between maternal chronic periodontitis and the risk of preterm birth and low birth weight in postpartum women. Methods: A total of 540 postpartum women were enrolled, comprising 270 cases (PTB and/or LBW) and 270 matched controls (term and normal birth weight). Demographic data and obstetric history were recorded. Periodontal status was assessed using the Clinical Attachment Loss (CAL) index, Gingival Index, and Community Periodontal Index of Treatment Needs (CPITN). Results: No significant differences were observed between groups regarding age, gravidity, or educational status (p > 0.05). However, periodontal indicators were significantly worse among cases. The mean CAL score was higher in the case group (4.18 ± 1.05) than controls (3.8 ± 0.83; p = 0.002). Gingival inflammation and CPITN scores also showed significant differences (p < 0.001) Conclusion: Maternal chronic periodontitis is significantly associated with preterm birth and low birth weight. Early diagnosis and management of periodontal disease in pregnant women may play a role in improving perinatal outcomes.

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Author Biographies

  • Manisha Pathak
    BDS, MDS (Periodontology), Associate Professor, Department of Dentistry, Saraswati Medical College, Unnao
  • Madhvika Patidar
    BDS, MDS, Assistant Professor, Department of Oral Pathology and Microbiology, Government College of Dentistry, Indore
  • John Kujur
    Reader, Department of Prosthodontics, Crown and Bridge, Implantology and Maxillofacial Prosthesis, Hi-Tech Dental College, Bhubaneshwar, Odisha
  • Himanshu Sharma
    Professor, Department of Pedodontics and Preventive Dentistry, College of Dental Science and Hospital, Rau, Indore
  • Shilpi Tyagi
    Senior Lecturer, ITS Dental College, D-1202 Charms Castle, Rajnagar Extension, Ghaziabad 201017
  • Akanksha Singh
    Senior Lecturer, ITS Dental College, Ghaziabad 201017

References

Gleason, C. A., & Devaskar, S. U. (2012). Avery’s diseases of the newborn (9th ed.). Saunders, an imprint of Elsevier Inc.

Marcdante, K. F., & Kliegman, R. M. (2011). Fetus and newborn. In R. E. Behrman & W. E. Nelson (Eds.), Essentials of pediatrics (6th ed.). WB Saunders.

Lockwood, C. J. (2002). Predicting premature delivery—no easy task. The New England Journal of Medicine, 346(4), 282–284. https://doi.org/10.1056/NEJM200201243460411

Romero, R., Chiquito, C. S., Elejalde, L. E., & Bernardoni, C. B. (2002). Relationship between periodontal disease in pregnant women and the nutritional condition of their newborns. Journal of Periodontology, 73(10), 1177–1183. https://doi.org/10.1902/jop.2002.73.10.1177

Carranza, F. A., Newman, M. G., Takei, H. H., & Klokkevold, P. R. (2006). Carranza’s clinical periodontology (10th ed., pp. 103–104). Saunders, an imprint of Elsevier.

Ebersole, J. L., & Cappelli, D. (2000). Acute-phase reactants in infections and inflammatory diseases. Periodontology 2000, 23(1), 19–49. https://doi.org/10.1034/j.1600-0757.2000.2230103.x

Offenbacher, S., Jared, H. L., O’Reilly, P. G., Wells, S. R., Salvi, G. E., & Lawrence, H. P. (1998). Potential pathogenic mechanisms of periodontitis-associated pregnancy complications. Annals of Periodontology, 3(1), 233–250. https://doi.org/10.1902/annals.1998.3.1.233

Ramfjord, S. P. (1959). Indices for prevalence and incidence of periodontal disease. Journal of Periodontology, 30(1), 51–59.

Ramfjord, S. P. (1967). The periodontal disease index (PDI). Journal of Periodontology, 38(4), 602–610.

Chattopadhyay, A., Arevalo, O., & Sohn, W. (2008). Understanding measurement of dental diseases and research participation in practice set-up. Dental Clinics of North America, 52(2), 367–386. https://doi.org/10.1016/j.cden.2007.12.006

Freitas, E., Meyer, K., Davis, R. K., & Kristoffersen, T. (1983). A baseline study of periodontal conditions among youths and adults in Portugal. Community Dentistry and Oral Epidemiology, 11(4), 250–254. https://doi.org/10.1111/j.1600-0528.1983.tb01747.x

Ramezani, E., & Ahmadinia, A. R. (2019). Evaluation of the Community Periodontal Index of Treatment Needs (CPITN) in dialysis patients referring to the hemodialysis department of 5th Azar Hospital in Gorgan City, 2017–2018. International Journal of Scientific Research in Dental and Medical Sciences, 1(2), 26–30. https://doi.org/10.30485/IJSRDMS.2019.189186.1006

Offenbacher, S., Katz, V., Fertik, G., Collins, J., Boyd, D., Maynor, G., et al. (1996). Periodontal infection as a possible risk factor for preterm low birth weight. Journal of Periodontology, 67(10 Suppl), 1103–1113. https://doi.org/10.1902/jop.1996.67.10s.1103

Xiong, X., Buekens, P., Fraser, W. D., Beck, J., & Offenbacher, S. (2006). Periodontal disease and adverse pregnancy outcomes: A systematic review. BJOG: An International Journal of Obstetrics & Gynaecology, 113(2), 135–143. https://doi.org/10.1111/j.1471-0528.2005.00827.x

Dörtbudak, O., Eberhardt, R., Ulm, M., & Persson, G. R. (2005). Periodontitis, a marker of risk in pregnancy for preterm birth. Journal of Clinical Periodontology, 32(1), 45–52. https://doi.org/10.1111/j.1600-051X.2004.00631.x

Vergnes, J. N., & Sixou, M. (2007). Preterm low birth weight and maternal periodontal status: A meta-analysis. American Journal of Obstetrics and Gynecology, 196(2), 135.e1–135.e7. https://doi.org/10.1016/j.ajog.2006.09.052

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Published

2025-04-22

How to Cite

Maternal Chronic Periodontitis as a Risk Factor for Preterm Birth and Low Birth Weight: A Hospital-Based Case Control Study. (2025). Academia Journal of Medicine, 8(1), 37-41. https://medjournal.co.in/index.php/ajm/article/view/241